Fluoroquinolone and Macrolide Treatment Failure in Pneumococcal Pneumonia and Selection of Multidrug-Resistant Isolates
نویسندگان
چکیده
Streptococcus pneumoniae serotype 3, isolated from a penicillin-allergic patient and initially susceptible to fluoroquinolones, macrolides, lincosamides, quinupristin-dalfopristin, and telithromycin, became resistant to all these drugs during treatment. Mutations in the parC and gyrA and in the 23S rRNA and the ribosomal protein L22 genes were detected in the resistant isolates.
منابع مشابه
Significance of macrolide resistance in Streptococcus pneumoniae.
Sir, We wish to comment on the paper by Van Kerkhoven et al.,1 to dispel certain misconceptions that may arise from a cursory review of their study. The authors present a 3 year retrospective chart review of patients hospitalized with pneumococcal bacteraemia at a single hospital. Of the 136 patients identified, 14 (10.3%) and 33 (24.3%) had isolates non-susceptible to penicillin and erythromyc...
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